Categoria: Bibliografia Selezionata

Azila-Gbettor EM et al. Student adjustment during Covid-19 pandemic: Exploring the moderating role of university support CELL, February 2023; doi.org/10.1016/j.heliyon.2023.e13625 Abstract The study investigates the moderating effect of university support on the association between fear of Cov19 and student adjustment including (a) academic; (b) psychological; and (c) social adjustment. A total of 592 students took…

ETIOLOGY – PATHOGENESIS – IMMUNOLOGY  Celardo I et al The immune system view of the coronavirus SARS-CoV-2 Biology Direct, December 2020; doi.org/10.1186/s13062-020-00283-2   Zhang L et al SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome MedRXiv, December 2020; doi: 10.1101/2020.12.12.422516   Huston NC et al Comprehensive in-vivo secondary structure of the SARS-CoV-2 genome reveals novel…

Fernando García-Dolores et al. Increased suicide rates in Mexico City during the COVID-19 pandemic outbreak: An analysis spanning from 2016 to 2021 Cell, May 2023; doi.org/10.1016/j.heliyon.2023.e16420 Abstract Coronavirus disease 2019 (COVID-19) has impacted mental health worldwide, and suicide can be a serious outcome of this. Thus, suicide characteristics were examined before and during the COVID-19…

So-Hee Hong et al. Immunization with RBD-P2 andN protects against SARS-CoV-2 in nonhuman primates Science Advances, https://www.science.org/doi/pdf/10.1126/sciadv.abg7156 CONTENUTO E COMMENTO : Studio pre-clinicocondotto su modello animale (topi, ratti e primati) finalizzato a valutare l’efficacia di un vaccinocomposto dalla fusionedell’epitopo T2 dellatossina del tetano e il RBD ricombinantedellaproteinaspike di Sars-CoV2 in modo da accrescerne l’immunogenicità, utilizzando come…

JOURNAL CLUB La produzione scientifica mondiale in tema di Infezione da SARS-CoV-2 e COVID-19, INIZIATA a partire da marzo 2020, è stata e continua ad essere copiosissima. Di conseguenza è veramente difficile orientarsi nell’informazione fra i vari aspetti del tema e selezionare gli articoli scientificamente più validi e innovativi. La Fondazione MISI (Malattie Infettive e…

BjörnCorleis et al. Efficacy of an unmodified bivalent mRNA vaccine against SARS-CoV-2 variants in female small animal models Nature, February 2023; doi.org/10.1038/s41467-023-36110-1 Abstract Combining optimized spike (S) protein-encoding mRNA vaccines to target multiple SARS-CoV-2 variants could improve control of the COVID-19 pandemic. We compare monovalent and bivalent mRNA vaccines encoding B.1.351 (Beta) and/or B.1.617.2 (Delta)…

Matthew C. Woodruff et al. Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID https://www.nature.com/articles/s41467-023-40012-7 Abstract While immunologic correlates of COVID-19 have been widely reported, their associations with post-acute sequelae of COVID-19 (PASC) remain less clear. Due to the wide array of PASC presentations, understanding if specific disease features associate with discrete immune processes and…

Gfeller D. et al. Improved predictions of antigen presentation and TCR recognition with MixMHCpred2.2 and PRIME2.0 reveal potent SARS-CoV-2 CD8+ T-cell epitopes CELL, January 2023; doi.org/10.1016/j.cels.2022.12.002 Abstract The recognition of pathogen or cancer-specific epitopes by CD8+ T cells is crucial for the clearance of infections and the response to cancer immunotherapy. This process requires epitopes…

Schneider J, et al. Postmortem investigation of fatalities following vaccination with COVID-19 vaccines Int J Legal Med. , https://link.springer.com/article/10.1007%2Fs00414-021-02706-9 CONTENUTO E COMMENTO : Questo studio riporta i dati di indagini post mortem eseguite su 18 persone decedute in seguito a somministrazione di vaccinazione anti COVID-19 (9 con Vaxzevria, 5 con Comirnaty, 3 con Spikevax, e 1 con…

Tetsuya Suzuki et al. Nasopharyngeal SARS-CoV-2 may not be dispersed by a high-flow nasal cannula Nature, February 2023 doi.org/10.1038/s41598-023-29740-4 Abstract A high-flow nasal cannula (HFNC) therapy plays a significant role in providing respiratory support to critically ill patients with coronavirus disease 2019 (COVID-19); however, the dispersion of the virus owing to aerosol generation is a…