Categoria: Bibliografia Selezionata

Quincy Hofsink et al Fourth mRNA COVID-19 vaccination in immunocompromised patients with haematological malignancies (COBRA KAI): a cohort study The Lancet, June 2023 ; doi.org/10.1016/j.eclinm.2023.102040 Abstract Patients with haematological malignancies have impaired antibody responses to SARS-CoV-2 vaccination. We aimed to investigate whether a fourth mRNA COVID-19 vaccination improved antibody quantity and quality. Methods In this cohort…

Antonios Douros et al. Common Vaccines and the Risk of Incident Dementia: A Population-based Cohort Study Academic.oup ; December 2022 ; doi.org/10.1093/infdis/jiac484 Abstract Observational studies suggesting that immunizations strongly decrease the risk of dementia had several methodological limitations. We assessed whether common vaccines are associated with the risk of dementia. Methods We assembled a population-based cohort of…

Minami Nagai et al. High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection Nature, June 2023; doi.org/10.1038/s41467-023-39569-0 Abstract Fever is a common symptom of influenza and coronavirus disease 2019 (COVID-19), yet its physiological role in host resistance to viral infection remains less clear. Here, we demonstrate that exposure of…

Joseph A. Lewnard et al. Increased vaccine sensitivity of an emerging SARS-CoV-2 variant Nature, June 2023 ;doi.org/10.1038/s41467-023-39567-2 Abstract Host immune responses are a key source of selective pressure driving pathogen evolution. Emergence of many SARS-CoV-2 lineages has been associated with enhancements in their ability to evade population immunity resulting from both vaccination and infection. Here we…

MariosKoutsakos et al. SARS-CoV-2 breakthrough infection induces rapid memory and de novo T cell responses Cell, February 2023; doi.org/10.1016/j.immuni.2023.02.017 Abstract While the protective role of neutralising antibodies against COVID-19 is well-established, questions remain about the relative importance of cellular immunity. Using 6 pMHC-multimers in a cohort with early and frequent sampling, we define the phenotype…

Stella T. Lartey et al. Evaluation of Unintended Consequences of COVID-19 Pandemic Restrictions and Obesity Prevalence Among Youths JAMA, July 2023; doi:10.1001/jamanetworkopen.2023.23596 Abstract Childhood obesity is linked to adulthood obesity and to childhood and adulthood noncommunicable diseases.1,2 Pandemic restrictions imposed in early 2020 contributed to decreased physical activity, reduced access to healthy foods, and increased…

Sok-Ja Janket et al Tachykinins and the potential causal factors for post-COVID-19 condition The Lancet, June 2023 ; doi.org/10.1016/S2666-5247(23)00111-8 Abstract The most prevalent symptoms of post-COVID-19 condition are pulmonary dysfunction, fatigue and muscle weakness, anxiety, anosmia, dysgeusia, headaches, difficulty in concentrating, sexual dysfunction, and digestive disturbances. Hence, neurological dysfunction and autonomic impairments predominate in post-COVID-19 condition.…

Arianna G. Cassidy et al. Assessment of Adverse Reactions, Antibody Patterns, and 12-month Outcomes in the Mother-Infant Dyad After COVID-19 mRNA Vaccination in Pregnancy JAMA, July 2023; doi:10.1001/jamanetworkopen.2023.23405 Abstract Importance  Longitudinal data on COVID-19 messenger RNA (mRNA) vaccine reactogenicity and immunogenicity in pregnancy and for the mother-infant dyad are needed. Objective  To examine COVID-19 mRNA…

Marc Raad et al. Stenotrophomonasmaltophilia pneumonia in critical COVID-19 patients Nature, February 2023; doi.org/10.1038/s41598-023-28438-x Abstract Stenotrophomonasmaltophilia, an environmental aerobic non-fermentative Gram-negative bacilli, has gained attention in many nosocomial outbreaks. COVID-19 patients in intensive care unit have extended hospital stay and are severely immunosuppressed. This study aimed to determine the prevalence and risk factors of S.…

Yang Yang et al. Viral and antibody dynamics of acute infection with SARS-CoV-2 omicron variant (B.1.529): a prospective cohort study from Shenzhen, China The Lancet, July 2023; doi.org/10.1016/S2666-5247(23)00139-8 Abstract Elucidating viral dynamics within the host is important for designing public health measures against SARS-CoV-2, particularly during the early stages of infection when transmission potential rapidly…