Categoria: Novità

BjörnCorleis et al. Efficacy of an unmodified bivalent mRNA vaccine against SARS-CoV-2 variants in female small animal models Nature, February 2023; doi.org/10.1038/s41467-023-36110-1 Abstract Combining optimized spike (S) protein-encoding mRNA vaccines to target multiple SARS-CoV-2 variants could improve control of the COVID-19 pandemic. We compare monovalent and bivalent mRNA vaccines encoding B.1.351 (Beta) and/or B.1.617.2 (Delta)…

Matthew C. Woodruff et al. Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID https://www.nature.com/articles/s41467-023-40012-7 Abstract While immunologic correlates of COVID-19 have been widely reported, their associations with post-acute sequelae of COVID-19 (PASC) remain less clear. Due to the wide array of PASC presentations, understanding if specific disease features associate with discrete immune processes and…

Gfeller D. et al. Improved predictions of antigen presentation and TCR recognition with MixMHCpred2.2 and PRIME2.0 reveal potent SARS-CoV-2 CD8+ T-cell epitopes CELL, January 2023; doi.org/10.1016/j.cels.2022.12.002 Abstract The recognition of pathogen or cancer-specific epitopes by CD8+ T cells is crucial for the clearance of infections and the response to cancer immunotherapy. This process requires epitopes…

Schneider J, et al. Postmortem investigation of fatalities following vaccination with COVID-19 vaccines Int J Legal Med. , https://link.springer.com/article/10.1007%2Fs00414-021-02706-9 CONTENUTO E COMMENTO : Questo studio riporta i dati di indagini post mortem eseguite su 18 persone decedute in seguito a somministrazione di vaccinazione anti COVID-19 (9 con Vaxzevria, 5 con Comirnaty, 3 con Spikevax, e 1 con…

Tetsuya Suzuki et al. Nasopharyngeal SARS-CoV-2 may not be dispersed by a high-flow nasal cannula Nature, February 2023 doi.org/10.1038/s41598-023-29740-4 Abstract A high-flow nasal cannula (HFNC) therapy plays a significant role in providing respiratory support to critically ill patients with coronavirus disease 2019 (COVID-19); however, the dispersion of the virus owing to aerosol generation is a…

Quincy Hofsink et al Fourth mRNA COVID-19 vaccination in immunocompromised patients with haematological malignancies (COBRA KAI): a cohort study The Lancet, June 2023 ; doi.org/10.1016/j.eclinm.2023.102040 Abstract Patients with haematological malignancies have impaired antibody responses to SARS-CoV-2 vaccination. We aimed to investigate whether a fourth mRNA COVID-19 vaccination improved antibody quantity and quality. Methods In this cohort…

Antonios Douros et al. Common Vaccines and the Risk of Incident Dementia: A Population-based Cohort Study Academic.oup ; December 2022 ; doi.org/10.1093/infdis/jiac484 Abstract Observational studies suggesting that immunizations strongly decrease the risk of dementia had several methodological limitations. We assessed whether common vaccines are associated with the risk of dementia. Methods We assembled a population-based cohort of…

Minami Nagai et al. High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection Nature, June 2023; doi.org/10.1038/s41467-023-39569-0 Abstract Fever is a common symptom of influenza and coronavirus disease 2019 (COVID-19), yet its physiological role in host resistance to viral infection remains less clear. Here, we demonstrate that exposure of…

Joseph A. Lewnard et al. Increased vaccine sensitivity of an emerging SARS-CoV-2 variant Nature, June 2023 ;doi.org/10.1038/s41467-023-39567-2 Abstract Host immune responses are a key source of selective pressure driving pathogen evolution. Emergence of many SARS-CoV-2 lineages has been associated with enhancements in their ability to evade population immunity resulting from both vaccination and infection. Here we…

MariosKoutsakos et al. SARS-CoV-2 breakthrough infection induces rapid memory and de novo T cell responses Cell, February 2023; doi.org/10.1016/j.immuni.2023.02.017 Abstract While the protective role of neutralising antibodies against COVID-19 is well-established, questions remain about the relative importance of cellular immunity. Using 6 pMHC-multimers in a cohort with early and frequent sampling, we define the phenotype…