Categoria: Novità

Jie Zhou et al. Viral emissions into the air and environment after SARS-CoV-2 human challenge: a phase 1, open label, first-in-human study The Lancet, June 2023 ; doi.org/10.1016/S2666-5247(23)00101-5 Abstract Effectively implementing strategies to curb SARS-CoV-2 transmission requires understanding who is contagious and when. Although viral load on upper respiratory swabs has commonly been used to infer…

Daniel Pan et al. Are clinical outcomes from COVID-19 improving in ethnic minority groups? The Lancet, July 2023; doi.org/10.1016/j.eclinm.2023.102091 Abstract Disproportionately worse COVID-19 clinical outcomes in people from ethnic minority groups have been a concern since early in the pandemic.1 Now as time progresses, it may be useful to look back at the evolving evidence…

Sho Nakakubo et al. Associations of COVID-19 symptoms with omicron subvariants BA.2 and BA.5, host status, and clinical outcomes in Japan: a registry-based observational study The Lancet, June 2023 ; doi.org/10.1016/S1473-3099(23)00271-2 Abstract Previous SARS-CoV-2 infection and vaccination, coupled with the rapid evolution of SARS-CoV-2 variants, have modified COVID-19 clinical manifestations. We aimed to characterise the clinical…

Renelle Myers et al. Breath testing for SARS-CoV-2 infection Lancet, April 2023; doi.org/10.1016/j.ebiom.2023.104584 Abstract From a public health perspective, the identification of individuals with mild respiratory symptoms due to SARS-CoV-2 infection is important to contain the spread of the disease. The objective of this study was to identify volatile organic compounds (VOCs) in exhaled breath…

Martin Potts et al. Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity Cell, May 2023 ; doi.org/10.1016/j.celrep.2023.112613 Abstract Certain serum proteins, including C-reactive protein (CRP) and D-dimer, have prognostic value in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nonetheless, these factors are non-specific, providing limited mechanistic insight into the…

Brian E. McGarry et al. Monoclonal Antibody and Oral Antiviral Treatment of SARS-CoV-2 Infection in US Nursing Homes JAMA, July 2023; doi:10.1001/jama.2023.12945 Abstract Nursing home residents are at elevated risk for severe infection from SARS-CoV-2,1 making them a priority for antiviral treatment.2 Although oral antiviral use has been found to be greater in nursing homes…